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d 4 coa  (Croda International Plc)

 
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    Structured Review

    Croda International Plc d 4 coa
    Chemical synthesis of C26:0 FFA- <t>d</t> <t>4</t> . A: C26:0 FFA was converted to the corresponding 8-aminoquinoline amide. Deuterium incorporation was first achieved selectively at the β-position under palladium catalysis, followed by the introduction of two deuterium atoms at the α-position using potassium carbonate. Finally, the resulting tetradeuterated amide was converted in two steps to furnish C26:0 FFA- d 4 . B: The ion spectra of the C26:0 FFA- d 4 obtained by a high-resolution mass spectrometer. ca ., circa; eq, equivalent; y., yield.
    D 4 Coa, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 94/100, based on 31 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/d 4 coa/product/Croda International Plc
    Average 94 stars, based on 31 article reviews
    d 4 coa - by Bioz Stars, 2026-03
    94/100 stars

    Images

    1) Product Images from "Phosphatidylcholine with C26:0 moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2"

    Article Title: Phosphatidylcholine with C26:0 moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2

    Journal: Journal of Lipid Research

    doi: 10.1016/j.jlr.2025.100973

    Chemical synthesis of C26:0 FFA- d 4 . A: C26:0 FFA was converted to the corresponding 8-aminoquinoline amide. Deuterium incorporation was first achieved selectively at the β-position under palladium catalysis, followed by the introduction of two deuterium atoms at the α-position using potassium carbonate. Finally, the resulting tetradeuterated amide was converted in two steps to furnish C26:0 FFA- d 4 . B: The ion spectra of the C26:0 FFA- d 4 obtained by a high-resolution mass spectrometer. ca ., circa; eq, equivalent; y., yield.
    Figure Legend Snippet: Chemical synthesis of C26:0 FFA- d 4 . A: C26:0 FFA was converted to the corresponding 8-aminoquinoline amide. Deuterium incorporation was first achieved selectively at the β-position under palladium catalysis, followed by the introduction of two deuterium atoms at the α-position using potassium carbonate. Finally, the resulting tetradeuterated amide was converted in two steps to furnish C26:0 FFA- d 4 . B: The ion spectra of the C26:0 FFA- d 4 obtained by a high-resolution mass spectrometer. ca ., circa; eq, equivalent; y., yield.

    Techniques Used: Mass Spectrometry

    Metabolic analysis of C26:0 FFA- d 4 in ABCD1 and LPLAT10-DKO HeLa cells. A: Schematic illustration of the possible metabolic pathway of exogenously administered C26:0 FFA- d 4 . Note that the C26:0- d 4 moiety is subjected to hydrolysis by lipases, resulting in C26:0 FFA- d 4 . B–K: The amounts of C26:0 FFA- d 4 (B) and lipid species with C26:0- d 4 moiety (C–K) present within HeLa cells. Data represent the mean ± SD; statistical analysis was performed using one-way ANOVA, followed by the Dunnett’s test (vs. ABCD1 KO). ∗P < 0.01, ∗∗P < 0.001. ACAT, acyl-CoA:cholesterol acyltransferase; CerS, ceramide synthase; DG, diacylglycerol; DGAT, diacylglycerol O-acyltransferase; DH-Sph, dihydrosphingosine; FC, free cholesterol; GSL, glycosphingolipid; MG, monoacylglycerol; MOGAT, monoacylglycerol O-acyltransferase; PAP, phosphatidic acid phosphatase; PLA 2 , phospholipase A 2 ; PLC, phospholipase C.
    Figure Legend Snippet: Metabolic analysis of C26:0 FFA- d 4 in ABCD1 and LPLAT10-DKO HeLa cells. A: Schematic illustration of the possible metabolic pathway of exogenously administered C26:0 FFA- d 4 . Note that the C26:0- d 4 moiety is subjected to hydrolysis by lipases, resulting in C26:0 FFA- d 4 . B–K: The amounts of C26:0 FFA- d 4 (B) and lipid species with C26:0- d 4 moiety (C–K) present within HeLa cells. Data represent the mean ± SD; statistical analysis was performed using one-way ANOVA, followed by the Dunnett’s test (vs. ABCD1 KO). ∗P < 0.01, ∗∗P < 0.001. ACAT, acyl-CoA:cholesterol acyltransferase; CerS, ceramide synthase; DG, diacylglycerol; DGAT, diacylglycerol O-acyltransferase; DH-Sph, dihydrosphingosine; FC, free cholesterol; GSL, glycosphingolipid; MG, monoacylglycerol; MOGAT, monoacylglycerol O-acyltransferase; PAP, phosphatidic acid phosphatase; PLA 2 , phospholipase A 2 ; PLC, phospholipase C.

    Techniques Used:



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    d 4 coa  (Croda International Plc)
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    Croda International Plc d 4 coa
    Chemical synthesis of C26:0 FFA- <t>d</t> <t>4</t> . A: C26:0 FFA was converted to the corresponding 8-aminoquinoline amide. Deuterium incorporation was first achieved selectively at the β-position under palladium catalysis, followed by the introduction of two deuterium atoms at the α-position using potassium carbonate. Finally, the resulting tetradeuterated amide was converted in two steps to furnish C26:0 FFA- d 4 . B: The ion spectra of the C26:0 FFA- d 4 obtained by a high-resolution mass spectrometer. ca ., circa; eq, equivalent; y., yield.
    D 4 Coa, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/d 4 coa/product/Croda International Plc
    Average 94 stars, based on 1 article reviews
    d 4 coa - by Bioz Stars, 2026-03
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    Image Search Results


    Chemical synthesis of C26:0 FFA- d 4 . A: C26:0 FFA was converted to the corresponding 8-aminoquinoline amide. Deuterium incorporation was first achieved selectively at the β-position under palladium catalysis, followed by the introduction of two deuterium atoms at the α-position using potassium carbonate. Finally, the resulting tetradeuterated amide was converted in two steps to furnish C26:0 FFA- d 4 . B: The ion spectra of the C26:0 FFA- d 4 obtained by a high-resolution mass spectrometer. ca ., circa; eq, equivalent; y., yield.

    Journal: Journal of Lipid Research

    Article Title: Phosphatidylcholine with C26:0 moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2

    doi: 10.1016/j.jlr.2025.100973

    Figure Lengend Snippet: Chemical synthesis of C26:0 FFA- d 4 . A: C26:0 FFA was converted to the corresponding 8-aminoquinoline amide. Deuterium incorporation was first achieved selectively at the β-position under palladium catalysis, followed by the introduction of two deuterium atoms at the α-position using potassium carbonate. Finally, the resulting tetradeuterated amide was converted in two steps to furnish C26:0 FFA- d 4 . B: The ion spectra of the C26:0 FFA- d 4 obtained by a high-resolution mass spectrometer. ca ., circa; eq, equivalent; y., yield.

    Article Snippet: C30:0-CoA, C28:0-CoA, C26:0-CoA, C24:0-CoA, and C16:0- d 4 -CoA were purchased from Avanti Polar Lipids, Inc. Ceramide (Cer) d18:1/16:0- d 31 , SM d18:1/16:0- d 31 , and lactosyl-Cer d18:1/17:0 were also obtained from Avanti Polar Lipids.

    Techniques: Mass Spectrometry

    Metabolic analysis of C26:0 FFA- d 4 in ABCD1 and LPLAT10-DKO HeLa cells. A: Schematic illustration of the possible metabolic pathway of exogenously administered C26:0 FFA- d 4 . Note that the C26:0- d 4 moiety is subjected to hydrolysis by lipases, resulting in C26:0 FFA- d 4 . B–K: The amounts of C26:0 FFA- d 4 (B) and lipid species with C26:0- d 4 moiety (C–K) present within HeLa cells. Data represent the mean ± SD; statistical analysis was performed using one-way ANOVA, followed by the Dunnett’s test (vs. ABCD1 KO). ∗P < 0.01, ∗∗P < 0.001. ACAT, acyl-CoA:cholesterol acyltransferase; CerS, ceramide synthase; DG, diacylglycerol; DGAT, diacylglycerol O-acyltransferase; DH-Sph, dihydrosphingosine; FC, free cholesterol; GSL, glycosphingolipid; MG, monoacylglycerol; MOGAT, monoacylglycerol O-acyltransferase; PAP, phosphatidic acid phosphatase; PLA 2 , phospholipase A 2 ; PLC, phospholipase C.

    Journal: Journal of Lipid Research

    Article Title: Phosphatidylcholine with C26:0 moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2

    doi: 10.1016/j.jlr.2025.100973

    Figure Lengend Snippet: Metabolic analysis of C26:0 FFA- d 4 in ABCD1 and LPLAT10-DKO HeLa cells. A: Schematic illustration of the possible metabolic pathway of exogenously administered C26:0 FFA- d 4 . Note that the C26:0- d 4 moiety is subjected to hydrolysis by lipases, resulting in C26:0 FFA- d 4 . B–K: The amounts of C26:0 FFA- d 4 (B) and lipid species with C26:0- d 4 moiety (C–K) present within HeLa cells. Data represent the mean ± SD; statistical analysis was performed using one-way ANOVA, followed by the Dunnett’s test (vs. ABCD1 KO). ∗P < 0.01, ∗∗P < 0.001. ACAT, acyl-CoA:cholesterol acyltransferase; CerS, ceramide synthase; DG, diacylglycerol; DGAT, diacylglycerol O-acyltransferase; DH-Sph, dihydrosphingosine; FC, free cholesterol; GSL, glycosphingolipid; MG, monoacylglycerol; MOGAT, monoacylglycerol O-acyltransferase; PAP, phosphatidic acid phosphatase; PLA 2 , phospholipase A 2 ; PLC, phospholipase C.

    Article Snippet: C30:0-CoA, C28:0-CoA, C26:0-CoA, C24:0-CoA, and C16:0- d 4 -CoA were purchased from Avanti Polar Lipids, Inc. Ceramide (Cer) d18:1/16:0- d 31 , SM d18:1/16:0- d 31 , and lactosyl-Cer d18:1/17:0 were also obtained from Avanti Polar Lipids.

    Techniques: